Active Form Folate Supplement
This methyl folate supplement delivers 1000mcg of L-methylfolate as 5-MTHF (5-methyltetrahydrofolate) per tablet. The active form enters your system without requiring conversion steps, making nutrients available for immediate use.
Each bottle contains 120 vegan tablets, providing a 4-month supply at one tablet daily. The formula contains no artificial colours, flavours, or preservatives.
Understanding Folate and Its Forms
Folate is a B vitamin (B9) essential for cell growth, DNA synthesis, and energy metabolism. The body needs folate for red blood cell formation and proper nervous system function.
Natural folate appears in foods like lentils, dark leafy greens, avocados, citrus fruits, beans, nuts, and squash. Synthetic folic acid appears in fortified foods and standard supplements.
The body must convert both dietary folate and synthetic folic acid into 5-MTHF before cells use the nutrient. This conversion process requires several enzymatic steps. Some individuals have genetic variations affecting this conversion efficiency.
L-methylfolate bypasses these conversion steps entirely. The supplement provides folate in the exact form your cells recognise and use directly.
Why Choose 5-MTHF Over Folic Acid
Standard folic acid supplements require your body to perform multiple conversion steps. Enzymes transform folic acid through dihydrofolate, then tetrahydrofolate, before reaching the active 5-MTHF form.
Genetic variations in the MTHFR enzyme affect up to 40% of the population. These variations reduce the body’s ability to convert folic acid efficiently, leading to potential folate insufficiency despite supplementation.
L-methylfolate eliminates this concern. The supplement delivers folate in its final, bioavailable form. Your cells receive the nutrient immediately without relying on conversion enzymes.
Bioavailability and Absorption
The 5-MTHF form crosses cell membranes and the blood-brain barrier efficiently. This enhanced bioavailability ensures folate reaches tissues throughout the body, including the central nervous system.
Studies show methylfolate achieves higher blood folate levels compared to equivalent doses of folic acid, particularly in individuals with MTHFR variations.
Folate Functions in the Body
- DNA Synthesis and Cell Division Folate provides one-carbon units essential for nucleotide synthesis. This process supports DNA replication and cell division, particularly in rapidly dividing tissues.
- Red Blood Cell Formation The bone marrow requires folate to produce healthy red blood cells. Adequate folate prevents megaloblastic anaemia, where red blood cells become abnormally large and dysfunctional.
- Homocysteine Metabolism Folate works with vitamins B6 and B12 to convert homocysteine into methionine. This process maintains healthy homocysteine levels in the blood.
- Amino Acid Metabolism Folate participates in amino acid conversions, supporting protein synthesis and metabolic processes throughout the body.
- Methylation Processes As 5-MTHF, folate donates methyl groups for numerous biochemical reactions. These methylation processes affect gene expression, neurotransmitter production, and cellular detoxification.
Formula Composition
Each tablet contains 1000mcg (1mg) of folate as calcium L-methylfolate. The vegan formula uses plant-based ingredients and avoids animal-derived components.
Firming and bulking agents provide tablet structure: calcium citrate, maltodextrin, microcrystalline cellulose, and modified starch. Anti-caking agents (silicon dioxide, magnesium stearate, talc) ensure smooth manufacturing.
The coating (methylcellulose and polyethylene glycol) protects the tablet and aids swallowing. No artificial colours, flavours, sweeteners, or preservatives appear in the formula.
Dosage and Administration
Take one tablet daily with a meal. Food enhances absorption and reduces potential stomach discomfort. Swallow the tablet whole with water.
Do not exceed one tablet per 24-hour period. Consistent daily intake maintains steady folate levels in your system.
Quality Standards
Carlyle manufactures this supplement following strict quality protocols. Each batch undergoes testing for purity and potency. The formula meets UK food supplement regulations.
Vegan certification ensures no animal products or by-products. The tablets contain no gluten, dairy, soya, or common allergens.
Who Should Use This Supplement
Adults aged 18-50 years seeking to maintain adequate folate levels through supplementation. Those following plant-based diets may benefit from additional folate support.
Individuals with confirmed or suspected MTHFR genetic variations who want the active folate form. People taking medications affecting folate metabolism should consult healthcare providers before starting supplementation.
Important Considerations
This product is not suitable for adults over 50 years old. Different folate requirements apply to this age group.
Pregnant women, breastfeeding mothers, and those taking medications must consult healthcare providers before use. Folate interacts with certain medications including methotrexate, anticonvulsants, and some antibiotics.
If you experience adverse reactions, discontinue use and seek medical advice. Store tablets in a cool, dry, dark location away from moisture and heat.
Key benefits list
- Active 5-MTHF Form Bioavailable L-methylfolate enters cells directly. No conversion steps required. Suitable for those with MTHFR variations.
- High Strength Dose 1000mcg folate per tablet delivers substantial nutritional support. One tablet daily meets supplementation needs.
- Enhanced Absorption Methylfolate crosses cell membranes efficiently. Achieves higher blood folate levels than standard folic acid supplements.
- Cell Growth Support Provides essential nutrients for DNA synthesis and cell division. Supports healthy tissue development and repair.
- Red Blood Cell Production Supplies folate needed for normal red blood cell formation. Helps maintain healthy blood cell size and function.
- Methylation Support Donates methyl groups for biochemical reactions. Supports gene expression and neurotransmitter production.
- 4-Month Supply 120 tablets provide extended supplementation. Reduces reorder frequency and ensures consistent intake.
- Clean Formula No artificial colours, flavours, or preservatives. Vegan-friendly with no animal-derived ingredients.
- Easy to Swallow Small tablet format with protective coating. Take once daily with food for optimal absorption.
- Quality Tested Each batch undergoes purity and potency testing. Manufactured following strict quality protocols.
Frequently Asked Questions
Folic acid is synthetic and requires enzymatic conversion to become active 5-MTHF in your body. Methyl folate provides the active 5-MTHF form directly, bypassing conversion steps. This makes methyl folate immediately available for your cells to use, particularly beneficial for individuals with MTHFR genetic variations affecting conversion efficiency.
Those with MTHFR genetic variations benefit most from active folate, as their bodies convert synthetic folic acid less efficiently. However, anyone seeking optimal folate bioavailability may prefer methyl folate. Genetic testing identifies MTHFR variations. Consult your healthcare provider about your individual needs.
Take one tablet daily with a meal. Food enhances folate absorption and reduces potential stomach discomfort. Choose morning or evening based on your routine. Consistency matters more than specific timing. Take at the same time each day for best results.
Adults over 50 have different nutritional requirements and may need different folate formulations or doses. High-dose folate supplementation in older adults requires medical supervision due to potential interactions with age-related conditions and medications. Consult your healthcare provider for age-appropriate folate supplementation.
Folate interacts with several medications including methotrexate (used for arthritis and cancer), anticonvulsants (epilepsy medications), sulfasalazine (inflammatory bowel disease), and some antibiotics. These medications affect folate absorption or metabolism. Always inform your healthcare provider about all supplements before starting new medications or supplement regimens.
